Why AC5® Advanced Wound System

AC5® Advanced Wound System is a POWERFUL solution for managing challenging wounds.

POWERFULLY VERSATILE

AC5® Advanced Wound System is the first self-assembling wound care solution to provide clinicians with multi-modal support.

Any Patient*

  • Pressure sores, leg ulcers, diabetic ulcers, and surgical wounds
  • Comorbidities and prior failed treatment
  • Regular and irregularly shaped wounds
  • MOA is agnostic to antithrombotic therapy

Any Place

  • Suitable for use in clinic and surgical settings
  • No cutting or sizing required
  • Room temperature storage
  • May be left in place during dressing changes

Any Time

  • Wound bed preparation and aggressive surgical debridement
  • Utility in all phases of wound healing
  • Acute, chronic, and stalled wounds
  • Surgical incisions, excisions, and biopsies
*Under the supervision of a health care professional, AC5® Advanced Wound System is indicated for the management of partial and full-thickness wounds.
AC5® Advanced Wound System should not be injected intravascularly. AC5® Advanced Wound System has not been tested in children and pregnant women.

POWERFULLY UNIQUE

AC5® self-assembling peptide technology outperforms the competition.
Wound Care Technology Provides Utility Across Healing Phases Conforms to Wound Provides Barrier to Mitigate Contamination & Modulate Inflammation Provides Scaffold to Enable Cell & Tissue Growth Resorbs Non-Antigenic
AC5® Advanced Wound System
Negative Pressure Therapy (NPWT) N/A N/A N/A
Hyperbaric Oxygen Therapy (HBOT) N/A N/A N/A
Skin Substitutes Some*
Collagen Matrices Some
Alginates Partially
Hydrocolloids and Hydrogels
Foams
Transparent Films
Data on File
*Some, in combination with adjunctive materials Provides extracellular matrix-mimicking scaffold

Powerfully Effective

AC5® Advanced Wound System is a unique self-assembling peptide technology with distinctive utility across all phases of wound healing.

AC5® Advanced Wound System

Barrier

  • Conforms to wound surface, geometry and/or irregularities
  • Forms physical mechanical seal
  • Provides moist healing environment
  • Provides protection that may mitigate contamination and modulate inflammation1,2

Scaffold

  • Creates extracellular matrix-like structure to enable cell and tissue growth
  • Aids in epithelial cell migration3
  • May reduce healing time and patient burden1,4,5,6,7
  • Naturally absorbed by the body
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Inflammatory

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Proliferative

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Remodeling

Phases of Wound Healing

  1. Anti-inflammatory effect of a self-assembling peptide (AC5®) in the lipopolysaccharide induced inflammation model of eye injury. Ellis-Behnke et al, Poster Presentation, MHSRS 08/18
  2. Effects of a self-assembling peptide on second degree burn progression and healing in a porcine model. Davis et al, Poster Presentation, SAWC Spring 2020
  3. Effects of a self-assembling peptide on full-thickness wound healing in a porcine model. Gil et al, Poster Presentation, SAWC Spring 2020
  4. A New Treatment Modality to Expedite Healing in the Case of a Transmetatarsal Breakdown. Jean W. Gillon, M.D. A Case Report Submitted to Journal of Vascular Surgery Cases and Innovative Techniques, April 2021.
  5. Rapid Healing of a Chronic Trophic Ulcer in a Patient with Peripheral Vascular and Autoimmune Comorbidities using a Novel Self-assembling Peptide-based Advanced Dressing. Laura Pfendler PT, DPT, Kalpana Kamath PhD, Daniel Wadsworth, Daniel Kapp, MD. Presented at SAWC Spring Virtual in May 2021.
  6. Healing of a Complex Surgical Wound using a Novel Self-Assembling Peptide-based Advanced Wound Dressing. Dan Kapp, MD and Terrence Norchi, MD. Presented at SAWC Fall Virtual in November 2020.
  7. Effective Management of a Non-healing Wound Post-Mohs Surgery using a Novel Self-assembling Peptide-based Advanced Wound Dressing. Laura Pfendler PT, DPT, Kalpana Kamath PhD, Daniel Wadsworth, Daniel Kapp, MD. Presented at SAWC Spring Virtual in May 2021.

Powerfully Simple

AC5® Advanced Wound System simplifies the complexities of managing challenging wounds and reduces patient at-home wound care burden.
  • Supplied as a lyophilized powder in a complete kit for reconstitution and application
  • Mix, apply via syringe, and cover with occlusive dressing
  • Naturally absorbed, which reduces risk of pain and/or damage to granulating tissue during dressing changes
  • Demonstrated effectiveness with 1x/week application
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POWERFULLY ALIGNED

AC5® Advanced Wound System supports best practices in wound care.
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Synthetic and bioabsorbable to reduce risk of
adverse effects

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Naturally conforms to diverse and challenging wound beds to enable optimal coverage

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Supports aggressive debridement in lower acuity clinic and non-OR settings

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Provides moist
healing
environment

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Provides extracellular matrix-like scaffold to enable granulation tissue formation and epithelialization

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Provides protective barrier to mitigate contamination and modulate inflammation

CASE STUDIES

With demonstrated effectiveness in even the most challenging wounds, AC5® Advanced Wound System is changing the healing experience.

100% Wound Healing in Challenging Wounds

4 Year Old Chronic Trophic Ulcer1

Patient: 59 year old female

Origin: A non-healing trophic ulcer on the left lateral malleolus. The patient had a complex medical history with multiple systemic comorbidities, including lupus, scleroderma with Raynaud’s phenomenon, small vessel peripheral vascular disease, and right below-the-knee amputation secondary to small vessel disease and a prior non-healing ulcer.

Prior Failed Therapy: Debridement, moist wound healing, nitro paste, and skin substitutes

Result: After 2 weekly treatments, the ulcer showed dramatic healing results, demonstrated by a greater than 90% reduction in wound volume. By day 19, the wound was completely epithelialized.

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  1. 1 Rapid Healing of a Chronic Trophic Ulcer in a Patient with Peripheral Vascular and Autoimmune Comorbidities using a Novel Self-assembling Peptide-based Advanced Dressing.
    Laura Pfendler PT, DPT, Kalpana Kamath PhD, Daniel Wadsworth, Daniel Kapp, MD. Presented at SAWC Spring Virtual in May 2021.

8 Week Old Complex
Lower Extremity Ulcer2

Patient: 66 year old female

Origin: Non-healing surgical site wound from local infection and wound dehiscence. Due to peripheral arterial disease the patient was not a candidate for compression dressings.

Prior Failed Therapy: Wet to dry dressings, collagenase ointment, and skin graft

Result: After 3 weekly treatments, the ulcer showed the formation of a healthy granulation tissue, thus allowing the patient to resume at-home wound care. The development of a stable granular wound bed and wound closure was achieved without the need for additional skin grafts.

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  1. 2 Healing of a Complex Surgical Wound using a Novel Self-Assembling Peptide-based Advanced Wound Dressing. Dan Kapp, MD and Terrence Norchi, MD. Presented at SAWC Fall Virtual in November 2020.

8 Week Old Post Mohs Pre-Tibial Wound3

Patient: 51 year old male

Origin: A non-healing surgical wound of the pre-tibial, right lower leg. The patient has a history of chronic deep vein thrombosis causing a right pulmonary artery chronic thrombus and idiopathic mediastinal fibrosis, as well as hypertension and dyspnea.

Prior Failed Therapy: Various topical antibiotics and non-adhesive pads

Result: After 4 weekly treatments with debridement, granulation tissue increased, the wound surface area progressively decreased 90% by the final application, and the wound had completely healed by the final follow-up visit at week six.

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  1. 3 Effective Management of a Non-healing Wound Post-Mohs Surgery using a Novel Self-assembling Peptide-based Advanced Wound Dressing. Laura Pfendler PT, DPT, Kalpana Kamath PhD, Daniel Wadsworth, Daniel Kapp, MD. Presented at SAWC Spring Virtual in May 2021.

Rapid Granulation And Life-Impacting Results in Previously Stalled Wounds

20 Year Old Chronic Refractory Burn1

Patient: 49 year old male

Origin: A chronic open friable wound due to the breakdown of severe scarring. The initial injury was an extensive burn across chest and flank that had occurred over two decades ago. The extreme friability of the wound, coupled with its presence in areas prone to continued friction with clothing, led to frequent and extensive bleeding.

Prior Failed Therapy: Repeat surgical debridement, APG (antibiofilm gel), non-adherent foams and dressings

Result: After only two treatments, the wound bed quality improved exhibiting a healthier tissue appearance, less exudate, less accumulation of slough on the wound surface, and new evidence of granulation buds. Cessation of intermittent bleeding episodes was noted, thus alleviating the burden of at-home wound care.

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  1. 1 Healing of a Chronic Refractory Burn Wound with a Novel Self-Assembling Peptide-based Advanced Wound Dressing. Randall Wolcott, and Kalpana Kamath, PhD.
    Presented at SAWC Fall Virtual in November 2020.

10 Year Old Decubitus Ulcer2

Patient: 47 year old male

Origin: An ischial decubitus ulcer that would not heal during the prior decade of standard care. The wound was subjected to repetitive trauma due to operation of heavy equipment, thus exacerbating the need for wound management. Wound microbiota included staphylococcus, Pseudomonas, and Candida.

Prior Failed Therapy: Topical agents and dressings

Result: After 6 weeks of every other week treatment with debridement, the wound approached 50% reduction in volume. Each dressing change required less packing and that a significant reduction in drainage and bleeding resulted in easier at-home wound care with fewer in-between clinic visits. The wound improved even though the patient continued to sit and this encouraged the patient to adhere to scheduled clinic visits, thus allowing for continued care and healing.

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  1. 2 Enabling Aggressive Surgical Debridement and Healing in a 10 year old Decubitus Ulcer with a Novel Self-Assembling Peptide-based Advanced Wound Dressing.
    Randall Wolcott, MD, Terrence Norchi, MD, Daniel Wadsworth, MS. Presented at Symposium on the Advancement of Wound Care 2020.

8 Month Old Transmetatarsal
Amputation Breakdown3

Patient: 65 year old male

Origin: A transmetatarsal amputation for gangrenous toes that slowly began to fail and had extensive dry and wet gangrene present. The patient had a history of hypertension, dialysis dependent renal failure, coronary artery bypass, and status post left below knee amputation.

Prior Failed Therapy: BKA post-op dressing changes

Result: After 3 weekly treatments with debridements and daily dressing changes, the wound shrank from 4 x 3 inches to 3 x 1.5 inches with a near 90% coverage of healthy pink granulation tissue. The serosanguinous drainage initially present also nearly abated and peripheral dry gangrene considerably diminished.

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  1. 3 A New Treatment Modality to Expedite Healing in the Case of a Transmetatarsal Breakdown. Jean W. Gillon, M.D. Submitted to Journal of Vascular Surgery April 2021.

KOL HIGHLIGHTS

Listen to wound care experts discuss how AC5® Advanced Wound System Wound is changing the healing experience.

MECHANISM
OF ACTION

Daniel L. Kapp, MD

Chief of Surgery at Palm Beach Gardens Medical Center discussing AC5® Advanced Wound System Mechanism of Action.

USE IN STALLED
WOUNDS

Randall Wolcott, MD

Founder of the Southwest Regional Wound Care Center, discussing why wound healing stalls and how AC5® Advanced Wound System may help.

USE IN COMPLICATED
WOUNDS

Daniel L. Kapp, MD

Chief of Surgery at Palm Beach Gardens Medical Center discussing using AC5® Advanced Wound System in complicated wounds.

EASE OF
APPLICATION

Laura Pfendler, Pt, DPT, CWS

Licensed physical therapist specializing in wound care, sharing her observations on applying AC5® Advanced Wound System.

SUPPORTING
IMPROVED QoL

Lee C. Rogers, DPM, FFPM, RCPS

Dr. Rogers from the American Board of Podiatric Medicine discussing how AC5® Advanced Wound System may help patients.

FULL KOL ROUNDTABLE
WEBCAST

Arch Therapeutics management and Key Opinion Leaders discuss AC5® Advanced Wound System
The ability of AC5 Advanced Wound System to quickly restart the previously stalled healing process may obviate the need for continued costly treatments as well as additional procedures, including skin grafts, thus reducing the total cost of lower extremity wound care. Daniel L. Kapp MD, Chief of Surgery at Palm Beach Gardens Medical Center
In a 94 year old with a 3 month old venous leg ulcer, we used AC5 Advanced Wound System and it healed after one application - the patient was thrilled! Laura Pfendler, PT, DPT, CWS, Licensed Physical Therapist Specializing in Wound Care and Lymphedema Management
AC5 Advanced Wound System is an effective, efficient and easy product to apply post debridement which allowed a much more robust debridement in the office leading to better wound healing outcomes. Randall Wolcott MD, Founder of the Southwest Regional Wound Care Center
The wound responded remarkably; the previously halted healing process recommenced and accelerated. Observations included excellent wound bed granulation, diminished hypertrophic wound margins, and at the time of this writing, the wound was approximately 95% healed and expected to achieve full closure. Furthermore, the novel product enabled more aggressive debridement. It was observed to possess hemostatic properties, such that bleeding was managed without the need for additional modalities. Lou D'Oro, MD, FACS, Wayne Memorial Hospital’s Advanced Wound Care and Hyperbaric Center
We observed rapid improvement of the wound with the formation of healthy granulation tissue, allowing the patient to resume at-home wound care with simple dressings sooner than otherwise anticipated. Daniel L. Kapp MD, Chief of Surgery at Palm Beach Gardens Medical Center
...if you have an innovative product like AC5 that is versatile in that it can be used for a variety of scenarios at any time during the life of the wound, a product that is easy to obtain and store, and a product that is not the most expensive on your shelf - then you have something special. Laura Pfendler, PT, DPT, CWS, Licensed Physical Therapist Specializing in Wound Care and Lymphedema Management
Statements provided by physicians who used the AC5® Advanced Wound Care System.  Your individual experience may vary.

PREP INSTRUCTIONS

AC5® Advanced Wound System is simple to store and easy to apply.

Download Preparation Instructions (PDF)

ORDERING INFO

Item Number AC5-1001

AC5® Advanced Wound System is supplied as a lyophilized powder in a complete single-use kit for reconstitution and application.

Qty Description of Sterilized Contents
1 AC5® Peptide Vial (3mL)
1 Water Vial (10 mL)
1 Syringe with Luer-Lok Tip (3mL)
1 Hypodermic Needle (18G x 1.5in)
2 Blunt Applicator (18G x 1.5in)
2 Alcohol Prep Pad (2 ply, medium, saturated with 70% isopropyl alcohol)
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Order AC5® Advanced Wound System

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