THE DIFFERENCE IS
AC5® SYNTHETIC SELF-ASSEMBLING PEPTIDE TECHNOLOGY
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Why AC5® Advanced Wound System
AC5® Advanced Wound System is a POWERFUL matrix for managing challenging wounds.
AC5® Advanced Wound System
Barrier
- Conforms to wound surface, geometry and/or irregularities
- Forms physical mechanical seal
- Provides microenvironment conducive to healing
- Provides protection that may mitigate contamination and modulate inflammation1,2
Scaffold
- Creates extracellular matrix-like structure to enable cell and tissue growth
- Aids in epithelial cell migration3
- May reduce healing time and patient burden1,4,5,6,7
- Naturally absorbed by the body
Inflammatory
Proliferative
Remodeling
Phases of Wound Healing
- Anti-inflammatory effect of a self-assembling peptide (AC5®) in the lipopolysaccharide induced inflammation model of eye injury. Ellis-Behnke et al, Poster Presentation, MHSRS 08/18
- Effects of a self-assembling peptide on second degree burn progression and healing in a porcine model. Davis et al, Poster Presentation, SAWC Spring 2020
- Effects of a self-assembling peptide on full-thickness wound healing in a porcine model. Gil et al, Poster Presentation, SAWC Spring 2020
- A New Treatment Modality to Expedite Healing in the Case of a Transmetatarsal Breakdown. Jean W. Gillon, M.D., Poster Presentation, SAWC Spring 2022.
- Rapid Healing of a Chronic Trophic Ulcer in a Patient with Peripheral Vascular and Autoimmune Comorbidities using a Novel Self-assembling Peptide-based Advanced Dressing. Laura Pfendler PT, DPT, Kalpana Kamath PhD, Daniel Wadsworth, Daniel Kapp, MD. Presented at SAWC Spring Virtual in May 2021.
- Healing of a Complex Surgical Wound using a Novel Self-Assembling Peptide-based Advanced Wound Dressing. Dan Kapp, MD and Terrence Norchi, MD. Presented at SAWC Fall Virtual in November 2020.
- Effective Management of a Non-healing Wound Post-Mohs Surgery using a Novel Self-assembling Peptide-based Advanced Wound Dressing. Laura Pfendler PT, DPT, Kalpana Kamath PhD, Daniel Wadsworth, Daniel Kapp, MD. Presented at SAWC Spring Virtual in May 2021.
- Supplied as a lyophilized powder in a complete kit for reconstitution and application
- Mix, apply via syringe, and cover with an appropriate dressing
- Naturally absorbed, which reduces risk of pain and/or damage to granulating tissue during dressing changes
- Demonstrated effectiveness with 1x/week application
Synthetic and bioabsorbable to reduce risk of
adverse effects
Naturally conforms to diverse and challenging wound beds to enable optimal coverage
Supports aggressive debridement in lower acuity clinic and non-OR settings
Provides microenvironment
conducive to
healing
Provides extracellular matrix-like scaffold to enable granulation tissue formation and epithelialization
Provides protective barrier to mitigate contamination and modulate inflammation
CASE STUDIES
With demonstrated effectiveness in even the most challenging wounds, AC5® Advanced Wound System is changing the healing experience.
100% Wound Healing in Challenging Wounds
4 Year Old Chronic Trophic Ulcer1
Patient: 59 year old female
Origin: A non-healing trophic ulcer on the left lateral malleolus. The patient had a complex medical history with multiple systemic comorbidities, including lupus, scleroderma with Raynaud’s phenomenon, small vessel peripheral vascular disease, and right below-the-knee amputation secondary to small vessel disease and a prior non-healing ulcer.
Prior Failed Therapy: Debridement, moist wound healing, nitro paste, and other skin substitutes
Result: After 2 weekly treatments, the ulcer showed dramatic healing results, demonstrated by a greater than 90% reduction in wound volume. By day 19, the wound was completely epithelialized.
Before
After
- 1 Rapid Healing of a Chronic Trophic Ulcer in a Patient with Peripheral Vascular and Autoimmune Comorbidities using a Novel Self-assembling Peptide-based Advanced Dressing.
Laura Pfendler PT, DPT, Kalpana Kamath PhD, Daniel Wadsworth, Daniel Kapp, MD. Presented at SAWC Spring Virtual in May 2021.
8 Week Old Complex
Lower Extremity Ulcer2
Patient: 66 year old female
Origin: Non-healing surgical site wound from local infection and wound dehiscence. Due to peripheral arterial disease the patient was not a candidate for compression dressings.
Prior Failed Therapy: Wet to dry dressings, collagenase ointment, and skin graft
Result: After 3 weekly treatments, the ulcer showed the formation of a healthy granulation tissue, thus allowing the patient to resume at-home wound care. The development of a stable granular wound bed and wound closure was achieved without the need for additional skin grafts.
Before
After
- 2 Healing of a Complex Surgical Wound using a Novel Self-Assembling Peptide-based Advanced Wound Dressing. Dan Kapp, MD and Terrence Norchi, MD. Presented at SAWC Fall Virtual in November 2020.
8 Week Old Post Mohs Pre-Tibial Wound3
Patient: 51 year old male
Origin: A non-healing surgical wound of the pre-tibial, right lower leg. The patient has a history of chronic deep vein thrombosis causing a right pulmonary artery chronic thrombus and idiopathic mediastinal fibrosis, as well as hypertension and dyspnea.
Prior Failed Therapy: Various topical antibiotics and non-adhesive pads
Result: After 4 weekly treatments with debridement, granulation tissue increased, the wound surface area progressively decreased 90% by the final application, and the wound had completely healed by the final follow-up visit at week six.
Before
After
- 3 Effective Management of a Non-healing Wound Post-Mohs Surgery using a Novel Self-assembling Peptide-based Advanced Wound Dressing. Laura Pfendler PT, DPT, Kalpana Kamath PhD, Daniel Wadsworth, Daniel Kapp, MD. Presented at SAWC Spring Virtual in May 2021.
Rapid Granulation And Life-Impacting Results in Previously Stalled Wounds
20 Year Old Chronic Refractory Burn1
Patient: 49 year old male
Origin: A chronic open friable wound due to the breakdown of severe scarring. The initial injury was an extensive burn across chest and flank that had occurred over two decades ago. The extreme friability of the wound, coupled with its presence in areas prone to continued friction with clothing, led to frequent and extensive bleeding.
Prior Failed Therapy: Repeat surgical debridement, APG (antibiofilm gel), non-adherent foams and dressings
Result: After only two treatments, the wound bed quality improved exhibiting a healthier tissue appearance, less exudate, less accumulation of slough on the wound surface, and new evidence of granulation buds. Cessation of intermittent bleeding episodes was noted, thus alleviating the burden of at-home wound care.
Before
After
- 1 Healing of a Chronic Refractory Burn Wound with a Novel Self-Assembling Peptide-based Advanced Wound Dressing. Randall Wolcott, and Kalpana Kamath, PhD.
Presented at SAWC Fall Virtual in November 2020.
10 Year Old Decubitus Ulcer2
Patient: 47 year old male
Origin: An ischial decubitus ulcer that would not heal during the prior decade of standard care. The wound was subjected to repetitive trauma due to operation of heavy equipment, thus exacerbating the need for wound management. Wound microbiota included staphylococcus, Pseudomonas, and Candida.
Prior Failed Therapy: Topical agents and dressings
Result: After 6 weeks of every other week treatment with debridement, the wound approached 50% reduction in volume. Each dressing change required less packing and the significant reduction in drainage and bleeding resulted in easier at-home wound care with fewer in-between clinic visits. The wound improved even though the patient continued to be immobile and this encouraged the patient to adhere to scheduled clinic visits, thus allowing for continued care and healing.
Before
After
- 2 Enabling Aggressive Surgical Debridement and Healing in a 10 year old Decubitus Ulcer with a Novel Self-Assembling Peptide-based Advanced Wound Dressing.
Randall Wolcott, MD, Terrence Norchi, MD, Daniel Wadsworth, MS. Presented at Symposium on the Advancement of Wound Care 2020.
8 Month Old Transmetatarsal
Amputation Breakdown3
Patient: 65 year old male
Origin: A transmetatarsal amputation for gangrenous toes that slowly began to fail and had extensive dry and wet gangrene present. The patient had a history of hypertension, dialysis dependent renal failure, coronary artery bypass, and status post left below knee amputation.
Prior Failed Therapy: BKA post-op dressing changes
Result: After 3 weekly treatments with debridements and daily dressing changes, the wound shrank from 4 x 3 inches to 3 x 1.5 inches with a near 90% coverage of healthy pink granulation tissue. The serosanguinous drainage initially present also nearly abated and peripheral dry gangrene considerably diminished.
Before
After
- 3 A New Treatment Modality to Expedite Healing in the Case of a Transmetatarsal Breakdown. Jean W. Gillon, M.D., Poster Presentation, SAWC Spring 2022.
KOL HIGHLIGHTS
Listen to wound care experts discuss how AC5® Advanced Wound System Wound is changing the healing experience.
Statements provided by physicians who used the AC5® Advanced Wound Care System. Your individual experience may vary.
PREP INSTRUCTIONS
AC5® Advanced Wound System is simple to store and easy to apply.
ORDERING INFO
| Qty | Description of Sterilized Contents |
|---|---|
| 1 | AC5® Peptide Vial (3mL) |
| 1 | Water Vial (10 mL) |
| 1 | Syringe with Luer-Lok™ Tip (3mL) |
| 2 | Hypodermic Needle (18G x 1.5in) |
| 1 | Blunt Applicator (18G x 1.5in) |
| 2 | Alcohol Prep Pad (2 ply, medium, saturated with 70% isopropyl alcohol) |
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